Publications

Selected Publications

  1. Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang, Linh T. Nguyen, Venkata S. K. Manem, Diana Gray, Michael Ryczko, Albiruni R. A. Razak, Jeremy Lewin, Stephanie Lheureux, Ilaria Colombo, Philippe L. Bedard, David Cescon, Anna Spreafico, Marcus O. Butler, Aaron R. Hansen, Raymond W. Jang, Sangeet Ghai, Ilan Weinreb, Valentin Sotov, Ramy Gadalla, Babak Noamani, Mengdi Guo, Sawako Elston, Amanda Giesler, Sevan Hakgor, Haiyan Jiang, Tracy McGaha, David G. Brooks, Benjamin Haibe-Kains, Trevor J. Pugh, Pamela S. Ohashi, and Lillian L. Siu. An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE). J Immunother Cancer. 2019; 7: 72.
  2. Roux C, Jafari SM, Shinde R, Duncan G, Cescon DW, Silvester J, Chu MF, Hodgson K, Berger T, Wakeham A, Palomero L, Garcia-Valero M, Pujana MA, Mak TW, McGaha TL, Cappello P, Gorrini C. Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1. PNAS. 2019. pii: 201819473.
  3. Snell LM, MacLeod BL, Law JC, Osokine I, Elsaesser HJ, Hezaveh K, Dickson RJ, Gavin MA, Guidos CJ, McGaha TL, Brooks DG. CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity. Immunity. 2018. 49(4):678-694.e5.
  4. Shinde R, Hezaveh K, Halaby MJ, Klotegen A, Chakravarthy A, Medina T, Deol R, Manion K, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn D, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither J, DeCarvalho D, McGaha TL. Apoptotic cell-induced, TLR9 dependent AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans. Nat Immunol. 2018. 2018 Jun;19(6):571-582. SELECTED FOR COVER ART.
  5. Sivaprakasam S, Gurav A, Paschall AV, Coe GL, Chaudhary K, Cai Y, Kolhe R, Martin P, Browning D, Huang L, Shi H, Sifuentes H, Vijay-Kumar M, Thompson SA, Munn DH, Mellor A, McGaha TL, Shiao P, Cutler CW, Liu K, Ganapathy V, Li H, Singh N. An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis. Oncogenesis. 2016. 5(6): e238. 
  6. Chen Y, Wermeling F, Kaiser Y, Winquist O, McGaha TL, Karlsson MCI. Selective memory for apoptotic cell derived self-antigens with implications for SLE development. J Immunol. 2016. 197(7): 2616-2626.
  7. Sharma M, McGaha T, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH. PTEN pathway in Tregs as a critical driver of the suppressive tumor microenvironment. Science Advances. 2015. 1(10): e1500845.
  8. Ravishankar B, Liu H, Shinde R, Chaudhary K, Xiao W, Bradley J, Kortizinsky M, Madaio M, McGaha TL. The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity. PNAS USA. 2015. 112(34): 10774-10779.
  9. Shinde R, Shimoda M, Chaudhary K, Liu H, Mohamed E, Bradley J, Kandala S, Li X, Liu K, McGaha TL. B cell-intrinsic IDO1 regulated humoral immunity to T cell-independent antigens. J Immunol. 2015195(5): 2374-2382.
  10. Chaudhary K, Shinde R, Liu H, Gnana-Prakasam J, Huang L, Ravishankar B, Bradley J, Kvirkvelia N, McManamin M, Kleven D, Mellor AL, Madaio MP, McGaha TL. Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy. J Immunol. 2015. 194(12): 5713-5724. SELECTED FOR COVER ART. SELECTED FOR JOURNAL CLUB IN SEPTEMBER 2015 ISSUE OF KIDNEY INTERNATIONAL
  11. Pashall A, Zhang R, Bardhan K, Chen-Feng Q, Peng L, Lu G, Yang J, Merad M, McGaha TL, Zhou G, Mellor AL, Abrams SI, Morse HC, Ozato, K, Xiong H, Liu K. IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation. J Immunol. 2015. 194(5): 2369-2379.
  12. Jha V, Workman C, McGaha TL, Li L, Vas J, Vignali DAA, Monestier M. Lymphocyte activation gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity. PLoS One. 2014. 9(8): e104484.
  13. Ravishankar B, Shinde R, Liu H, Chaudhary K, Lemos H, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha TL. Marginal zone CD169+macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance. PNAS USA. 2014.111(11): 4215-4220. SELECTED BY FACULTY OF 1000.
  14. Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Munn DH, Mellor AL, McGaha TL. GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Mol Cell Biol. 2014. 34(4): 428-438.
  15. Huang L, Li L, Lemos H, Chandler P, Pacholczyk G, Baban B, Barber G, Hayakawa H, McGaha TL, Munn DH, Mellor AL. Nanoparticle cargo DNA promotes potent tolerogenic responses by selective STING activation in myeloid dendritic cells. Cutting Edge, J Immunol. 2013.191(7): 3509-3513.
    • Link | Pubmed
  16. Chaudhary K, Kleven D, McGaha TLMadaio M. A human monoclonal antibody against the collagen type IV a3NC1 domain is a non-invasive optical biomarker for glomerular disease. Kidney Int. 2013. 84(2): 403-408SELECTED FOR COMMENTARY AND ISSUE COVER ART.
  17. Huang L, Lemos HP, Li L, Chandler PR, Baban B, McGaha TL, Ravishankar B, Lee JR, Munn DH, Mellor AL. Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells. J Immunol. 2012. 188(10): 4913-4920.
  18. Yang D, Torres CM, Bardhan K, Zimmerman M, McGahaTL, Kiu K. Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to fas ligand-induced apoptosis in vitro and tumor suppression in vivo. J Immunol. 2012. 188(9): 4441-4449.
  19. McGaha TL, Ma Z, Gabunia K, Ravishankar B, McMenamin M, Madaio MP. Heterologous protein incites abnormal plasma cell accumulation and autoimmunity in MRL-MpJ mice. Autoimmunity. 2012. 45(4): 279-289.
  20. Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, Munn DH, Mellor AL, Karlsson MC, McGaha TL. Tolerance to apoptotic cells is regulated by indoleamine 2,3 dioxygenase. PNAS USA. 2012. 109(10): 3909-3914. SELECTED BY FACULTY OF 1000.
  21. Enoksson SL, Grasset EK, Hagglof T, Mattsson N, Kaiser Y, Gabrielsson S, McGaha TL, Scheynius A, Karlsson MC. The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells. PNAS USA. 2011. 108(5):E1399-1407.
  22. McGaha TL, Chen Y, Ravishankar B, van Rooijen N, Karlsson MCI. Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen. Blood 2011. 117(20): 5403-5412
  23. Shao W, Zhen Y, Rosenbaum J, Eisenberg RA, McGaha TL, Birkenbach M, Cohen PL. A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis. J Clin Immunol. 2010. 136(2): 236-244.
  24. McGaha TL*Karlsson MCI, Ravetch JV. FcgRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. J Immunol. 2008. 180(8): 5670-5679.
  25. Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, Schneider P, Huard B, Lambert PH, Siegrist CA. April is critical for plasmablast survival in the bone marrow and poorly expressed by early life bone marrow stromal cells. Blood. 2008. 111(5): 2755-2764
  26. Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med. 2006. 203:553-561.
  27. McGaha TL, Sorrentino B, Ravetch JV. Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science. 2005. 307:590-593. 

 

Invited Reviews 

  1. Shinde R, McGaha TL. The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment. Trends Immunol. 2018. 39(12):1005-1020.
  2. Snell L, McGaha TL, Brooks DG. Type I interferon in chronic virus infection and cancer. Trends Immunol. 2017. 38(8): 542-557.SELECTED FOR FEATURE REVIEW AND COVER ART.
  3. McGaha TL, Karlsson MCI. Apoptotic cell tolerance in the marginal zone: a paradigm for acquired tolerance in the periphery. Immunol Rev. 2016. 269(1): 26-43.
  4. McGaha TL. IDO-GCN2 and autophagy in inflammation. Oncotarget. 2015. 6(26): 21771-21772.
  5. Lemos H, Huang L, McGaha T, Mellor AL. STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy? Expert Rev Clin Immunol. 2015. 11(1): 155-165.
  6. McGaha TL, Madaio M. Lupus nephritis: animal modeling of a complex disease syndrome pathology. Drug discovery today: disease models. 2014. 11: 13-18.
  7. Lemos H, Huang L, McGaha TL, Mellor AL. Cytosolic DNA sensing via the stimulator of interferon genes adaptor: yin and yang of immune responses to DNA. Eur J Immunol. 2014. 44(10): 2847-2853.
  8. Ravishankar B, McGaha TL. O death where is thy sting? Immunologic tolerance towards apoptotic self. Cell Mol Life Sci. 2013. 70(19): 3571-3589.
  9. McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL. Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. Immunol Rev. 2012.  249(1):135-157.
  10. Wermeling F, Karlsson MCI, McGaha TL. An anatomical view on macrophages in tolerance. Autoimmun Rev. 2009. 9(1): 49-52.

 

Full List of Publications

Full list of publications on Google Scholar