Publications

Selected Publications

  1. Hezaveh K, Shinde RS, Klötgen A, Halaby MJ, Lamorte S, Ciudad MT, Quevedo R, Neufeld L, Liu ZQ, Jin R, Grünwald BT, Foerster EG, Chaharlangi D, Guo M, Makhijani P, Zhang X, Pugh TJ, Pinto DM, Co IL, McGuigan AP, Jang GH, Khokha R, Ohashi PS, O'Kane GM, Gallinger S, Navarre WW, Maughan H, Philpott DJ, Brooks DG, McGaha TL. Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity. Immunity. 2022 Feb 8;55(2):324-340.e8.
  2. Snell LM, Xu W, Abd-Rabbo D, Boukhaled G, Guo M, Macleod BL, Elsaesser HJ, Hezaveh K, Alsahafi N, Lukhele S, Nejat S, Prabhakaran R, Epelman S, McGaha TL, Brooks DG. Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection. Nat Immunol. 2021 Dec;22(12):1524-1537.
  3. Sharma MD, Pacholczyk R, Shi H, Berrong ZJ, Zakharia Y, Greco A, Chang CS, Eathiraj S, Kennedy E, Cash T, Bollag RJ, Kolhe R, Sadek R, McGaha TL, Rodriguez P, Mandula J, Blazar BR, Johnson TS, Munn DH. Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity. Immunity. 2021 Oct 12;54(10):2354-2371.e8.
  4. Cindy Yang SY, Lien SC, Wang BX, Clouthier DL, Hanna Y, Cirlan I, Zhu K, Bruce JP, El Ghamrasni S, Iafolla MAJ, Oliva M, Hansen AR, Spreafico A, Bedard PL, Lheureux S, Razak A, Speers V, Berman HK, Aleshin A, Haibe-Kains B, Brooks DG, McGaha TL, Butler MO, Bratman SV, Ohashi PS, Siu LL, Pugh TJ. Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity.Nat Commun. 2021 Aug 26;12(1):5137.
  5. Halaby MJ, McGaha TL. Amino Acid Transport and Metabolism in Myeloid Function. eCollection 2021.
  6. Zhen Y, McGaha TL, Finkelman FD, Shao WH. The Akt-mTORC1 pathway mediates Axl receptor tyrosine kinase-induced mesangial cell proliferation. J Leukoc Biol. 2021 Jul 4
  7. Halaby MJ, McGaha TL. 2-HG modulates glioma macrophages via Trp metabolism. Nat Cancer. 2021 Jul;2(7):677-679.
  8. Lamorte S, Shinde R, McGaha TL. Nuclear receptors, the aryl hydrocarbon receptor, and macrophage function. Mol Aspects Med. 2021 Apr;78:100942.
  9. Macleod BL, Elsaesser HJ, Snell LM, Dickson RJ, Guo M, Hezaveh K, Xu W, Kothari A, McGaha TL, Guidos C, Brooks DG. A network of immune and microbial modifications underlies viral persistence in the gastrointestinal tract. J Exp Med. 2020. 27(12).
  10. Romero JM, Jang GH, Bavi PP, Jhaveru A, Masonnmian M, Fischer SE, Zhang A, Denroche RE, Lungu IM, De Luca A, Bartlett JMS, Xu J, Miandong L, Dhaliwal S, Liang SB, Chadwick D, Vyas F, Bronsert P, Kokha R, McGaha TL, Notta F, Ohashi PS, Done SJ, O’Kane GM, Wilson JM, Knox JJ, Connor A, Wang Y, Zogopoulos G,Gallinger S. A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer. Clin. Cancer Res. 2020. 26(8).
  11. Halaby MJ, Hezaveh K, Lamorte S, Ciudad-Garcia T, Kloetgen A, MacLeod B, Guo M, Chakarvarthy A, Da Silva Medina T, Ugel S, Dickson RJ, Tsirigos A, Bronte V, Munn DH, Pugh TJ, DeCarvalho DD, Butler MO, Ohashi PS, Brooks DG, McGaha TL. GCN2 drives macrophage and MDSC function and immune suppression in the tumor microenvironment. Science Immunology. 2019. 4(42).
  12. Gadalla R, Nomani B, Macleod BL, Dickson RJ, Guo M, Xu W, Lukhele S, Elaesser HJ, Razak ARA, Hirano N, McGaha TL, Wang B, Butler M, Guidos CJ, Ohashi PS, Siu LL, Brooks DG. Validation of CyTOF against flow cytometry for immunological studies and monitoring of human cancer clinical trials. Front. Oncology. 2019. 9:415
  13. Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang, Linh T. Nguyen, Venkata S. K. Manem, Diana Gray, Michael Ryczko, Albiruni R. A. Razak, Jeremy Lewin, Stephanie Lheureux, Ilaria Colombo, Philippe L. Bedard, David Cescon, Anna Spreafico, Marcus O. Butler, Aaron R. Hansen, Raymond W. Jang, Sangeet Ghai, Ilan Weinreb, Valentin Sotov, Ramy Gadalla, Babak Noamani, Mengdi Guo, Sawako Elston, Amanda Giesler, Sevan Hakgor, Haiyan Jiang, Tracy McGaha, David G. Brooks, Benjamin Haibe-Kains, Trevor J. Pugh, Pamela S. Ohashi, and Lillian L. Siu. An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE). J Immunother Cancer. 2019; 7: 72.
  14. Roux C, Jafari SM, Shinde R, Duncan G, Cescon DW, Silvester J, Chu MF, Hodgson K, Berger T, Wakeham A, Palomero L, Garcia-Valero M, Pujana MA, Mak TW, McGaha TL, Cappello P, Gorrini C. Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1. PNAS. 2019. pii: 201819473.
  15. Snell LM, MacLeod BL, Law JC, Osokine I, Elsaesser HJ, Hezaveh K, Dickson RJ, Gavin MA, Guidos CJ, McGaha TL, Brooks DG. CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity. Immunity. 2018. 49(4):678-694.e5.
  16. Shinde R, Hezaveh K, Halaby MJ, Klotegen A, Chakravarthy A, Medina T, Deol R, Manion K, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn D, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither J, DeCarvalho D, McGaha TL. Apoptotic cell-induced, TLR9 dependent AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans. Nat Immunol. 2018. 2018 Jun;19(6):571-582. SELECTED FOR COVER ART.
  17. Sivaprakasam S, Gurav A, Paschall AV, Coe GL, Chaudhary K, Cai Y, Kolhe R, Martin P, Browning D, Huang L, Shi H, Sifuentes H, Vijay-Kumar M, Thompson SA, Munn DH, Mellor A, McGaha TL, Shiao P, Cutler CW, Liu K, Ganapathy V, Li H, Singh N. An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis. Oncogenesis. 2016. 5(6): e238. 
  18. Chen Y, Wermeling F, Kaiser Y, Winquist O, McGaha TL, Karlsson MCI. Selective memory for apoptotic cell derived self-antigens with implications for SLE development. J Immunol. 2016. 197(7): 2616-2626.
  19. Sharma M, McGaha T, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH. PTEN pathway in Tregs as a critical driver of the suppressive tumor microenvironment. Science Advances. 2015. 1(10): e1500845.
  20. Ravishankar B, Liu H, Shinde R, Chaudhary K, Xiao W, Bradley J, Kortizinsky M, Madaio M, McGaha TL. The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity. PNAS USA. 2015. 112(34): 10774-10779.
  21. Shinde R, Shimoda M, Chaudhary K, Liu H, Mohamed E, Bradley J, Kandala S, Li X, Liu K, McGaha TL. B cell-intrinsic IDO1 regulated humoral immunity to T cell-independent antigens. J Immunol. 2015. 195(5): 2374-2382.
  22. Chaudhary K, Shinde R, Liu H, Gnana-Prakasam J, Huang L, Ravishankar B, Bradley J, Kvirkvelia N, McManamin M, Kleven D, Mellor AL, Madaio MP, McGaha TL. Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy. J Immunol. 2015. 194(12): 5713-5724. SELECTED FOR COVER ART. SELECTED FOR JOURNAL CLUB IN SEPTEMBER 2015 ISSUE OF KIDNEY INTERNATIONAL
  23. Pashall A, Zhang R, Bardhan K, Chen-Feng Q, Peng L, Lu G, Yang J, Merad M, McGaha TL, Zhou G, Mellor AL, Abrams SI, Morse HC, Ozato, K, Xiong H, Liu K. IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation. J Immunol. 2015. 194(5): 2369-2379.
  24. Jha V, Workman C, McGaha TL, Li L, Vas J, Vignali DAA, Monestier M. Lymphocyte activation gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity. PLoS One. 2014. 9(8): e104484.
  25. Ravishankar B, Shinde R, Liu H, Chaudhary K, Lemos H, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha TL. Marginal zone CD169+macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance. PNAS USA. 2014.111(11): 4215-4220. SELECTED BY FACULTY OF 1000.
  26. Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Munn DH, Mellor AL, McGaha TL. GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Mol Cell Biol. 2014. 34(4): 428-438.
  27. Huang L, Li L, Lemos H, Chandler P, Pacholczyk G, Baban B, Barber G, Hayakawa H, McGaha TL, Munn DH, Mellor AL. Nanoparticle cargo DNA promotes potent tolerogenic responses by selective STING activation in myeloid dendritic cells. Cutting Edge, J Immunol. 2013.191(7): 3509-3513.
  28. Chaudhary K, Kleven D, McGaha TL, Madaio M. A human monoclonal antibody against the collagen type IV a3NC1 domain is a non-invasive optical biomarker for glomerular disease. Kidney Int. 2013. 84(2): 403-408. SELECTED FOR COMMENTARY AND ISSUE COVER ART.
  29. Huang L, Lemos HP, Li L, Chandler PR, Baban B, McGaha TL, Ravishankar B, Lee JR, Munn DH, Mellor AL. Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells. J Immunol. 2012. 188(10): 4913-4920.
  30. Yang D, Torres CM, Bardhan K, Zimmerman M, McGahaTL, Kiu K. Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to fas ligand-induced apoptosis in vitro and tumor suppression in vivo. J Immunol. 2012. 188(9): 4441-4449.
  31. McGaha TL, Ma Z, Gabunia K, Ravishankar B, McMenamin M, Madaio MP. Heterologous protein incites abnormal plasma cell accumulation and autoimmunity in MRL-MpJ mice. Autoimmunity. 2012. 45(4): 279-289.
  32. Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, Munn DH, Mellor AL, Karlsson MC, McGaha TL. Tolerance to apoptotic cells is regulated by indoleamine 2,3 dioxygenase. PNAS USA. 2012. 109(10): 3909-3914. SELECTED BY FACULTY OF 1000.
  33. Enoksson SL, Grasset EK, Hagglof T, Mattsson N, Kaiser Y, Gabrielsson S, McGaha TL, Scheynius A, Karlsson MC. The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells. PNAS USA. 2011. 108(5):E1399-1407.
  34. McGaha TL, Chen Y, Ravishankar B, van Rooijen N, Karlsson MCI. Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen. Blood 2011. 117(20): 5403-5412
  35. Shao W, Zhen Y, Rosenbaum J, Eisenberg RA, McGaha TL, Birkenbach M, Cohen PL. A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis. J Clin Immunol. 2010. 136(2): 236-244.
  36. McGaha TL*, Karlsson MCI, Ravetch JV. FcgRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. J Immunol. 2008. 180(8): 5670-5679.
  37. Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, Schneider P, Huard B, Lambert PH, Siegrist CA. April is critical for plasmablast survival in the bone marrow and poorly expressed by early life bone marrow stromal cells. Blood. 2008. 111(5): 2755-2764
  38. Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med. 2006. 203:553-561.
  39. McGaha TL, Sorrentino B, Ravetch JV. Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science. 2005. 307:590-593. 

 

Invited Reviews 

  1. Shinde R, McGaha TL. The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment. Trends Immunol. 2018. 39(12):1005-1020.
  2. Snell L, McGaha TL, Brooks DG. Type I interferon in chronic virus infection and cancer. Trends Immunol. 2017. 38(8): 542-557.SELECTED FOR FEATURE REVIEW AND COVER ART.
  3. McGaha TL, Karlsson MCI. Apoptotic cell tolerance in the marginal zone: a paradigm for acquired tolerance in the periphery. Immunol Rev. 2016. 269(1): 26-43.
  4. McGaha TL. IDO-GCN2 and autophagy in inflammation. Oncotarget. 2015. 6(26): 21771-21772.
  5. Lemos H, Huang L, McGaha T, Mellor AL. STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy? Expert Rev Clin Immunol. 2015. 11(1): 155-165.
  6. McGaha TL, Madaio M. Lupus nephritis: animal modeling of a complex disease syndrome pathology. Drug discovery today: disease models. 2014. 11: 13-18.
  7. Lemos H, Huang L, McGaha TL, Mellor AL. Cytosolic DNA sensing via the stimulator of interferon genes adaptor: yin and yang of immune responses to DNA. Eur J Immunol. 2014. 44(10): 2847-2853.
  8. Ravishankar B, McGaha TL. O death where is thy sting? Immunologic tolerance towards apoptotic self. Cell Mol Life Sci. 2013. 70(19): 3571-3589.
  9. McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL. Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. Immunol Rev. 2012.  249(1):135-157.
  10. Wermeling F, Karlsson MCI, McGaha TL. An anatomical view on macrophages in tolerance. Autoimmun Rev. 2009. 9(1): 49-52.

 

Full List of Publications

Full list of publications on Google Scholar